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By William C. Raschke (auth.), Stewart Sell, Britta Wahren (eds.)

The skill to diagnose melanoma through uncomplicated dimension of a serum or tissue' 'marker" has been a aim of clinical technological know-how for a few years. there's plentiful facts that tumor cells are various from general cells and seasoned­ duce components that may be detected by means of at present to be had immuno­ chemical or biochemical equipment. those "cancer markers" might be se­ creted proteins, enzymes, hormones, fetal serum parts, monoclonal immunoglobulins, telephone floor elements, or cytoplasmic ingredients. the aim of this publication is to provide the present prestige of our wisdom of such melanoma markers. the 1st tumor marker pointed out by way of laboratory capacity was once Bence­ Jones protein. In a chain of lectures dropped at the Royal collage of Phy­ sicians in London in 1846, Dr. H. Bence Jones defined reviews on a urine pattern despatched to him with the subsequent be aware: "Dear Dr. Jones-The tube includes urine of very excessive particular gravity. while boiled it turns into a bit of opaque . . . . and so on. " Dr. Jones chanced on that heating of the urine after addition of nitric acid led to formation of a heavy precipitate; acid advert­ dition can have been required to deliver the urine to pH 4-6 at which Bence Jones proteins usually tend to precipitate while heated. This urinary pre­ cipitate used to be linked to a bone disorder termed "mollities ossium. " [H. Bence Jones, Papers on Chemical Pathology, Lecture III. Lancet 2, 269-274 (1847)].

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